Local immunotherapy with ONCOS-102 shapes harmful tumor associated CD68+ macrophages to become beneficial cells that correlate with increased overall survival

نویسندگان

  • Sari Pesonen
  • Johan Lundin
  • Nina Linder
  • Riku Turkki
  • Ari Ristimäki
  • Timo Joensuu
  • Kalevi Kairemo
  • Kaarina Partanen
  • Tuomo Alanko
  • Elke Jäger
  • Julia Karbach
  • Claudia Wahle
  • Akseli Hemminki
  • Charlotta Backman
  • Mikael von Euler
  • Tiina Hakonen
  • Tuuli Ranki
  • Antti Vuolanto
  • Magnus Jäderberg
  • Dmitry Zamarin
چکیده

Local immunotherapy with ONCOS-102 shapes harmful tumor associated CD68+ macrophages to become beneficial cells that correlate with increased overall survival Sari Pesonen, Johan Lundin, Nina Linder, Riku Turkki, Ari Ristimäki, Timo Joensuu, Kalevi Kairemo, Kaarina Partanen, Tuomo Alanko, Elke Jäger, Julia Karbach, Claudia Wahle, Akseli Hemminki, Charlotta Backman, Mikael von Euler, Tiina Hakonen, Tuuli Ranki, Antti Vuolanto, Magnus Jäderberg, Dmitry Zamarin

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Phase I study with ONCOS-102 for the treatment of solid tumors – an evaluation of clinical response and exploratory analyses of immune markers

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Local treatment of a pleural mesothelioma tumor with ONCOS-102 induces a systemic antitumor CD8+ T-cell response, prominent infiltration of CD8+ lymphocytes and Th1 type polarization

Late stage cancer is often associated with reduced immune recognition and a highly immunosuppressive tumor microenvironment. The presence of tumor infiltrating lymphocytes (TILs) and specific gene-signatures prior to treatment are linked to good prognosis, while the opposite is true for extensive immunosuppression. The use of adenoviruses as cancer vaccines is a form of active immunotherapy to ...

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Tumor-associated macrophages correlate with the clinicopathological features and poor outcomes via inducing epithelial to mesenchymal transition in oral squamous cell carcinoma

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2015